Pollution Prevention

Prevention of Air, Water, and Soil Pollution

Sumitomo Pharma has identified “Legal Compliance and Prevention of Environmental Accidents” as one of the foundational issues in our medium- to long-term environmental targets. As a pharmaceutical company that uses chemical substances in manufacturing and research activities, we recognize our responsibility to prevent adverse impacts on both the environment and human health and are committed to pollution prevention.

In accordance with the Air Pollution Control Act, Water Pollution Prevention Act, and other applicable regulations, we regularly monitor exhaust gas emissions and effluent quality, and submit required notifications for regulated facilities. We also implement measures to prevent pollution caused by hazardous substances and continuously monitor effluent quality, including pH levels. In our production sites and certain research sites, we have established voluntary standards that are more stringent than the effluent standards set by the Water Pollution Prevention Act to ensure appropriate effluent management.

At Suzuka Plant and Central Research Laboratories, production and research sites located within our premises, we have installed multiple monitoring wells and regularly monitor groundwater. If soil investigations are required under the Soil Contamination Countermeasures Act or relevant local ordinances, we conduct them in compliance with legal requirements and take appropriate actions in consultation with relevant authorities based on the results.

To prepare for environmental incidents, we have established company-wide emergency response policies under the Rules for Emergency Response. Each site has also developed detailed response procedures to minimize potential impacts in the event of an emergency. In addition, we investigate the causes of incidents, implement corrective and preventive actions as necessary, and maintain procedures to verify the effectiveness of such measures.

Air Emissions

We monitor and measure the emissions of NOx (Nitrogen Oxides), SOx (Sulfur Oxides), and particulate matter contained in exhaust gases from cogeneration systems and boilers. Following the shutdown of the cogeneration system at the Suzuka Plant in fiscal 2025, emissions of these substances decreased.

Water Discharges

We monitor BOD (Biochemical Oxygen Demand) and COD (Chemical Oxygen Demand) loads in wastewater as indicators of our impact on aquatic environments.

BOD and COD Load

Effort to Reduce Chemical Substance Releases

The chemical substances handled in the largest quantities include toluene, methanol, and acetone. These substances are primarily used as solvents, and most are eventually treated appropriately as waste, such as waste oil. We strive to reduce the quantities handled and implement measures such as recovery systems for volatile solvents, including dichloromethane, to reduce releases to the environment.

In fiscal 2025, all our sites subject to reporting under Japan's PRTR^*1 system submitted the required notifications. 　

Chemical Substance Released Related Indicators

• *1PRTR: Pollutant Release and Transfer Register
• *2VOCs: Volatile Organic Compounds
• *3 Releases to air and public water. No releases to soil.
• *4 In fiscal 2025, the calculation methodology for certain VOC emissions was revised, and the reported emissions reflect the impact of this change.

For more information on the calculation standards, please see "ESG Data Table."

Environmental Risk Assessment of Pharmaceuticals

When active pharmaceutical ingredients (APIs) are released into the environment, their biological activity may adversely affect non-target organisms and consequently affect ecosystem health and resilience. One source of pharmaceutical releases to the environment is direct discharge from pharmaceutical manufacturing processes^*5.

The release of antibiotics into the environment has been identified as a potential contributor to the emergence and spread of antimicrobial resistance (AMR). Based on estimates from the O’Neill Review in the United Kingdom, the United Nations has warned that annual deaths attributable to AMR could reach 10 million by 2050 if resistance rates continue to increase without adequate countermeasures^*6. Antibiotics released into the environment through wastewater or waste generated during manufacturing processes may contribute to antimicrobial resistance and thereby increase the risk of widespread infectious diseases.

At our API manufacturing site, various measures are implemented to reduce antibiotic releases to the environment. These include neutralization (decomposition) treatment of antibiotics in wastewater, activated sludge treatment at wastewater treatment facilities, incineration of a portion of high-concentration equipment cleaning wastewater, and decontamination of solid waste prior to disposal through inactivation by spraying it with sodium hypochlorite solution. We verify through periodic internal audits of our API manufacturing site that the Predicted Environmental Concentration (PEC) of antibiotics in factory effluent remains below the Predicted No-Effect Concentrations (PNEC-MIC^*7 and PNEC-ENV^*8).

In our assessment of nature-related issues based on the TNFD recommendations, “Pollution (Impact)” has been identified as one of our key issues. We will continue our efforts to reduce the environmental impacts of pharmaceuticals and chemical substances and address nature-related issues.

For more information, please see "Biodiversity".

• *5Pharmaceuticals in the Environment | UNEP - UN Environment Programme
• *6New report calls for urgent action to avert antimicrobial resistance crisis
• *7 PNEC-MIC: Predicted No-Effect Concentration calculated based on Minimum Inhibitory Concentration (MIC) data for microorganisms.
• *8PNEC-ENV: Predicted No-Effect Concentration calculated based on ecotoxicity test data for environmental organisms, including fish, invertebrates, and algae.
　　

*7, *8 PNEC table：https://www.amrindustryalliance.org/2026-changes-to-the-pnec

Prevention of Noise, Vibration, and Offensive Odors

We implement appropriate measures and conduct continuous monitoring in accordance with applicable laws and regulations related to the prevention of noise, vibration, and offensive odors.

Proper Disposal of PCBs

In accordance with the Act on Special Measures concerning Promotion of Proper Treatment of PCB Waste, we have completed the proper disposal of all polychlorinated biphenyl (PCB)-containing equipment and PCB waste in our possession.